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GNE-7883
CAS No. 2648450-42-2
GNE-7883( —— )
Catalog No. M37199 CAS No. 2648450-42-2
GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 311 | In Stock |
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| 5MG | 282 | In Stock |
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| 10MG | 455 | In Stock |
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| 25MG | 747 | In Stock |
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| 50MG | 1004 | In Stock |
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| 100MG | 1414 | In Stock |
|
| 200MG | 1841 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGNE-7883
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.
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DescriptionGNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation. GNE-7883 may be used in the study of YAP/TAZ-dependent cancers.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorYAP
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Research Area——
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Indication——
Chemical Information
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CAS Number2648450-42-2
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Formula Weight500.57
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Molecular FormulaC28H29FN6O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (199.77 mM; Ultrasonic )
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SMILESO=C1C=C(NC2=C(C(=O)N3CC(CF)C3)C(=NN12)C=4N=CC=NC4C)C=5C=CC(=CC5)C6CCCCC6
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hagenbeek TJ, et al. An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance. Nat Cancer. 2023 Jun;4(6):812-828.?
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