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ROS-generating?agent?1
CAS No. 2369030-41-9
ROS-generating?agent?1( —— )
Catalog No. M37110 CAS No. 2369030-41-9
Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 68 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 346 | In Stock |
|
| 100MG | 578 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1190 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameROS-generating?agent?1
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NoteResearch use only, not for human use.
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Brief DescriptionRos-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR.
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DescriptionROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetFerroptosis
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RecptorFerroptosis | ROS Kinase | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2369030-41-9
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Formula Weight411.34
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Molecular FormulaC21H15F6NO
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (81.03 mM; Ultrasonic )
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SMILESC(=C\1/C(=O)\C(=C\C2=CC(C(F)(F)F)=CC=C2)\CNC1)\C3=CC(C(F)(F)F)=CC=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191.?
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