Cart
sales@molnova.com
Home - Products - Others - Other Targets - BMS-502

BMS-502

CAS No. 2407854-18-4

BMS-502( —— )

Catalog No. M37109 CAS No. 2407854-18-4

BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 297 In Stock
10MG 464 In Stock
25MG 778 In Stock
50MG 1004 In Stock
100MG 1386 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    BMS-502
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells.
  • Description
    BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research.
  • In Vitro
    ——
  • In Vivo
    Animal Model:OT-1 mouse model Dosage:0-10 mg/kg Administration:Oral administration; 24 h Result:Caused no significant increase in activated effector T-cells.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2407854-18-4
  • Formula Weight
    516.5
  • Molecular Formula
    C27H22F2N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (193.61 mM; Ultrasonic (<80°C)
  • SMILES
    N#CC1=NC2=C(N(C)C(C([N+]([O-])=O)=C2N3CCN(C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3)=O)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chupak L, et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12;14(7):929-935.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Phenibut (hydrochlor...

    Phenibut (hydrochloride)?is a GABA mimetic that acts as an agonist at GABAB receptors, blocks α2δ subunit-containing voltage-gated calcium channels, stimulates dopamine receptors, and inhibits the actions of β-phenethylamine.

  • Sodium Nitroprusside

    Sodium Nitroprusside is a potent vasodilator working through releasing NO spontaneously in blood.

  • Micronomicin

    Micronomicin is an antibiotic exhibiting antibacterial and bactericidal capacity.

Sign In Join Free