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GPX4-IN-6

CAS No. 2922824-07-3

GPX4-IN-6( —— )

Catalog No. M37107 CAS No. 2922824-07-3

GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 61 Get Quote
10MG 92 Get Quote
25MG 174 Get Quote
50MG 273 Get Quote
100MG 430 Get Quote
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Biological Information

  • Product Name
    GPX4-IN-6
  • Note
    Research use only, not for human use.
  • Brief Description
    GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.
  • Description
    GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM.GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GPX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2922824-07-3
  • Formula Weight
    426.23
  • Molecular Formula
    C18H17BrFNO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (117.31 mM; Ultrasonic )
  • SMILES
    O=C(N(C1=CC=C2OCCOC2=C1)C3=CC(OC)=C(F)C(OC)=C3)CBr
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059.
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