GPX4-IN-5( —— )

Catalog No. M37105 CAS No. 2922824-09-5

GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	104	In Stock
5MG	93	In Stock
10MG	150	In Stock
25MG	256	In Stock
50MG	365	In Stock
100MG	544	In Stock
200MG	775	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

GPX4-IN-5
Note

Research use only, not for human use.
Brief Description

GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.
Description

GPX4-IN-5 (Compound C18) is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM.GPX4-IN-5 (Compound C18) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

GPX
Research Area

——
Indication

——

Chemical Information

CAS Number

2922824-09-5
Formula Weight

381.78
Molecular Formula

C18H17ClFNO5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (261.93 mM; Ultrasonic )
SMILES

O=C(N(C1=CC=C2OCCOC2=C1)C3=CC(OC)=C(F)C(OC)=C3)CCl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059.

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