Cart
sales@molnova.com
Tyrosine kinase-IN-7
CAS No. 345615-74-9
Tyrosine kinase-IN-7( —— )
Catalog No. M37096 CAS No. 345615-74-9
Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity in a variety of cancer cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 29 | In Stock |
|
| 10MG | 38 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTyrosine kinase-IN-7
-
NoteResearch use only, not for human use.
-
Brief DescriptionTyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity in a variety of cancer cell lines.
-
DescriptionTyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayImmunology/Inflammation
-
TargetAntiviral
-
RecptorAntiviral | EGFR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number345615-74-9
-
Formula Weight297.38
-
Molecular FormulaC16H15N3OS
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESOC1=CC=C(NC2=NC=NC3=C2C2=C(CCCC2)S3)C=C1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Elmetwally SA, et al. Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers. Bioorg Chem. 2019 Jul;88:102944.?
molnova catalog
related products
-
BIT225
BIT225 is a human immunodeficiency virus type 1 Vpu inhibitor with antiviral activity that inhibits HIV-1 replication in bone marrow dendritic cells and inhibits ion channels formed by HIV-1 Vpu.
-
SARS-CoV-2 nsp13-IN-...
SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent inhibitor of nsp13 (non-structural protein 13), selectively inhibiting nsp13 ssDNA+ATPase with an IC50 of 6 μM, but not ssDNA-ATPase, and can be used to study COVID-19.
-
2-C-beta-Methylguano...
2'-C-beta-Methylguanosine (2'-C-Methylguanosine) is a metabolite of the hepatitis C virus nucleotide polymerase inhibitor, BMS-986094, which has antiviral activity and inhibits dengue virus 2.
