TT-012( —— )

Catalog No. M37093 CAS No. 1164471-33-3

TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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2MG	58	In Stock
5MG	85	In Stock
10MG	140	In Stock
25MG	273	In Stock
50MG	449	In Stock
100MG	709	In Stock
500MG	1431	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

TT-012
Note

Research use only, not for human use.
Brief Description

TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter.
Description

TT-012 specifically binds to dynamic MITF and destroys the latter's dimer formation and DNA-binding ability. TT-012 inhibits the transcriptional activity of MITF in B16F10 melanoma cells. TT-012 inhibits the growth of high-MITF melanoma cells, and inhibits the tumor growth and metastasis with tolerable toxicity to liver and immune cells in animal models.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

1164471-33-3
Formula Weight

349.34
Molecular Formula

C19H15N3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (286.25 mM; Ultrasonic )
SMILES

N(C(/C=C/C1=CC=CO1)=O)C=2N=C(NC(/C=C/C3=CC=CO3)=O)C=CC2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Liu Z, et al. A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res. 2023 Jan;33(1):55-70. ?

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