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Tubulin polymerization-IN-43

CAS No. 2773345-90-5

Tubulin polymerization-IN-43( —— )

Catalog No. M37016 CAS No. 2773345-90-5

Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerisation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 197 In Stock
25MG 326 In Stock
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Biological Information

  • Product Name
    Tubulin polymerization-IN-43
  • Note
    Research use only, not for human use.
  • Brief Description
    Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerisation.
  • Description
    Tubulin polymerization-IN-43 (compound 15h) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-43 disrupts cellular microtubule networks by targeting the Colchicine (HY-16569) site, and promots cell cycle arrest of leukemia cells at G2/M phase and cell apoptosis, as well as inhibiting angiogenesis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis | Microtubule Associated
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2773345-90-5
  • Formula Weight
    351.3
  • Molecular Formula
    C17H13F4N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(C)(C=1C2=C(N=C(C(F)(F)F)N1)C=CC(F)=C2)C3=CC=C(OC)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wu H, et, al. Discovery of novel N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as the inhibitors of tubulin polymerization in leukemia cells. Eur J Med Chem. 2023 Aug 5;256:115470.?
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