Antiviral agent 34

Research use only, not for human use.

Antiviral agent 34 is an orally available, potent antiviral compound that inhibits influenza A and B viruses.

Antiviral agent 34 is a potent and orally active antiviral agent against influenza A and B subtypes with an EC50 value of 0.8 nM for H1N1 proliferation. Antiviral agent 34 derivatives inhibited influenza virus proliferation by targeting influenza virus RNA-dependent RNA polymerase. Antiviral agent 34 can be used for influenza virus research.

Cell Viability Assay Cell Line:MDCK cellsConcentration:0-470 nMIncubation Time:24 h Result:Exhibited low toxicity to MDCK cells.Western Blot Analysis Cell Line:MDCK cells Concentration:2-125 nM Incubation Time:24 h Result:Reduced the protein level of H1N1 nucleocapsid protein (NP) with low nanomolar values.Real Time qPCR Cell Line:MDCK cells Concentration:2-31.3 nM Incubation Time:24 h Result:Reduced the mRNA level of H1N1 nucleocapsid protein (NP) with low nanomolar values.

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Immunology/Inflammation

Antiviral

Antiviral | DNA/RNA Synthesis

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945152-88-5

487.66

C29H33N3O2S

>98% (HPLC)

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O=C(NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C3=CC=C(C=C3)C(C)(C)C

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(-20℃)

With Ice Pack

≥ 2 years