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LMTK3-IN-1

CAS No. 2764850-23-7

LMTK3-IN-1( —— )

Catalog No. M36996 CAS No. 2764850-23-7

Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 29 In Stock
5MG 46 In Stock
10MG 71 In Stock
25MG 119 In Stock
50MG 177 In Stock
100MG 256 In Stock
200MG 356 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    LMTK3-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway.
  • Description
    LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    c-Met/HGFR
  • Recptor
    c-Met/HGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2764850-23-7
  • Formula Weight
    356.3
  • Molecular Formula
    C18H11F3N4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 5 mg/mL (14.03 mM; Ultrasonic (<60°C)
  • SMILES
    FC(F)(F)OC1=CC=CC(=C1)C2=CN=C3C=CC(=NN32)C=4C=CN=CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Agnarelli A, et al. The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. Int J Mol Sci. 2023 Jan 3;24(1):865.?
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