MHI-148( —— )

Catalog No. M36944 CAS No. 172971-76-5

MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection, diagnosis, and study of cancer.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

MHI-148
Note

Research use only, not for human use.
Brief Description

MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection, diagnosis, and study of cancer.
Description

MHI-148 is a near-infrared heptamethine cyanine dye with tumor-targeting properties for cancer detection, diagnosis and research. MHI-148 is immediately taken up and accumulated by lysosomes and mitochondria of tumor cells, but not in lysosomes and mitochondria of normal cells.
In Vitro

MHI-148 (10 μM, 1 h)?is significantly more absorbed in HT-29 colon carcinoma cells than in normal NIH3T3 fibroblasts and has tumor imaging and targeting properties. MHI-148 (0-1.5 μM, 3 days) causes only negligible toxicity in HT-29 and NIH3T3 cells.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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Chemical Information

CAS Number

172971-76-5
Formula Weight

764.23
Molecular Formula

C42H52BrClN2O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 20.83 mg/mL (27.26 mM; Ultrasonic )
SMILES

[Br-].O=C(O)CCCCCN1C=2C=CC=CC2C(C1=CC=C3C(Cl)=C(C=CC4=[N+](C=5C=CC=CC5C4(C)C)CCCCCC(=O)O)CCC3)(C)C
Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Athira Raveendran, et al. Heptamethine Cyanine Dye MHI-148-Mediated Drug Delivery System to Enhance the Anticancer Efficiency of Paclitaxel. Int J Nanomedicine. 2021 Oct 21;16:7169-7180.?

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