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URAT1 inhibitor 7

CAS No. 1632002-28-8

URAT1 inhibitor 7( —— )

Catalog No. M36929 CAS No. 1632002-28-8

URAT1 inhibitor 7 is a novel and potent inhibitor of the human uric acid transporter protein URAT1 (IC50:12 nM).URAT1 inhibitor 7 inhibits CYP2C9 with an IC50 of 4.2 μM.URAT1 inhibitor 7 can be used to study hyperuricemia and gout.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    URAT1 inhibitor 7
  • Note
    Research use only, not for human use.
  • Brief Description
    URAT1 inhibitor 7 is a novel and potent inhibitor of the human uric acid transporter protein URAT1 (IC50:12 nM).URAT1 inhibitor 7 inhibits CYP2C9 with an IC50 of 4.2 μM.URAT1 inhibitor 7 can be used to study hyperuricemia and gout.
  • Description
    URAT1 inhibitor 7 (compound 10f) is a potent URAT1 inhibitor, with an IC50 of 12 nM. URAT1 inhibitor 7 exhibits microsomal stability (HLM <13 μL/min/mg). URAT1 inhibitor 7 also inhibits CYP2C9, with an IC50 of 4.2 μM. URAT1 inhibitor 7 can be used for gout research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    OAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1632002-28-8
  • Formula Weight
    428.82
  • Molecular Formula
    C19H10ClFN4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N#CC1=CC=C(OC2=CC=C(C=C2C#N)S(=O)(=O)NC3=NC=C(F)C=C3)C=C1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Storer R I, et al. The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout. MedChemComm, 2016:10.1039.C6MD00190D.
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