Mitazalimab( —— )

Catalog No. M36813 CAS No. 2055640-86-1

Mitazalimab (ADC-1013; JNJ-64457107) is an FcγR-dependent CD40 agonist that targets tumors by activating antigen-presenting cells like dendritic cells (DC), initiating tumor-reactive T cells, promoting tumor-specific T cell infiltration and destruction of tumors, and remodeling the tumor-infiltrating myeloid microenvironment .

Purity : >98% (HPLC)

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Biological Information

Product Name

Mitazalimab
Note

Research use only, not for human use.
Brief Description

Mitazalimab (ADC-1013; JNJ-64457107) is an FcγR-dependent CD40 agonist that targets tumors by activating antigen-presenting cells like dendritic cells (DC), initiating tumor-reactive T cells, promoting tumor-specific T cell infiltration and destruction of tumors, and remodeling the tumor-infiltrating myeloid microenvironment .
Description

Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment.
In Vitro

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In Vivo

Animal Model:MB49-tumor bearing mice model Dosage:10, 30, 100 or 300 μg/mouse Administration:Intraperitoneal injection; on day 7, 10 and 13 post-inoculation; sampled at 24 h after final dose Result: Increased the level of IP-10, MIP-1α and TNF-α, but not CXCL1, IFN-γ, IL-6, IL-10, MCP-1 and MIP-2.Resulted in increased frequency of CD44hi CD62L-efector memory CD8+ and CD4+ T cells.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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Chemical Information

CAS Number

2055640-86-1
Formula Weight
Molecular Formula

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Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Deronic A, et al. The human anti-CD40 agonist antibody mitazalimab (ADC-1013; JNJ-64457107) activates antigen-presenting cells, improves expansion of antigen-specific T cells, and enhances anti-tumor efficacy of a model cancer vaccine in vivo. Cancer Immunol Immunother. 2021 Dec;70(12):3629-3642. ?

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