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Carotuximab

CAS No. 1268714-50-6

Carotuximab( —— )

Catalog No. M36777 CAS No. 1268714-50-6

Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Carotuximab
  • Note
    Research use only, not for human use.
  • Brief Description
    Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity.
  • Description
    Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions.
  • In Vitro
    Western Blot Analysis Cell Line:Human aortic endothelial cells (HAoECs) Concentration:300 μg/mL Incubation Time:Pretreatment 1 h, and then co-cultured for 12 h Result:Reduced the 7-Ketocholesterol-induced Eng protein levels and pSmad1/5 and pSmad2/3 signaling.
  • In Vivo
    Animal Model:Female NSG (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ; 7-8 weeks) injected with primary AML-0032 cells Dosage:2 mg/kg Administration:i.v; every 3 days; for 8 weeks Result:Along with Decitabine resulted in a more durable anti-leukemic effect in AML xenografts.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TGF-beta/Smad | Immunology/Inflammation related
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1268714-50-6
  • Formula Weight
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Katarina Tripska , et al. Monoclonal anti-endoglin antibody TRC105 (carotuximab) prevents hypercholesterolemia and hyperglycemia-induced endothelial dysfunction in human aortic endothelial cells. Front Med (Lausanne). 2022 Sep 7;9:845918.?
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