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Talquetamab
CAS No. 2226212-40-2
Talquetamab( —— )
Catalog No. M36758 CAS No. 2226212-40-2
Talquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 415 | In Stock |
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| 5MG | 687 | In Stock |
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| 10MG | 1102 | In Stock |
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| 25MG | 1634 | In Stock |
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| 50MG | 2158 | In Stock |
|
| 100MG | 2911 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTalquetamab
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NoteResearch use only, not for human use.
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Brief DescriptionTalquetamab (JNJ-64407564) is a GPRC5D bispecific antibody for multiple myeloma (MM) that induces T-cell-mediated killing of GPRC5-expressing MM cells through T-cell recruitment and activation, demonstrating antitumor activity.
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DescriptionTalquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity.
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In Vitro——
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In VivoAnimal Model:Female NSG mice with H929 cells Dosage:0.1-10 μg (0.005 mg/kg) Administration:Subcutaneous injection; on days 0, 3, 5, 7, and 10 Result:Completely blocked tumor formation at 1 μg and 10 μg doses. Animal Model:Female NSG mice with human MM cells Dosage:0.1-50 μg (0.005 mg/kg) Administration:Intravenous injection; on days 15, 18, 22, 24, 29, 32, and 36 Result:Significantly inhibited tumor growth by 65% at the dose of 1μg and showed significant anti-tumor activity at 10 and 50 μg with complete tumor regression.
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Synonyms——
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorDopamine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2226212-40-2
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Formula Weight
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Christie P M Verkleij, et al. Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma. Blood Adv. 2021 Apr 27;5(8):2196-2215.?
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