Ponsegromab( —— )

Catalog No. M36709 CAS No. 2368950-15-4

Ponsegromab (PF 06946860) is a selective and effective humanized anti-GDF15 antibody inhibitor with anti-cachexic activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Ponsegromab
Note

Research use only, not for human use.
Brief Description

Ponsegromab (PF 06946860) is a selective and effective humanized anti-GDF15 antibody inhibitor with anti-cachexic activity.
Description

Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 antibody inhibitor with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

TGF-beta/Smad
Research Area

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Indication

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Chemical Information

CAS Number

2368950-15-4
Formula Weight
Molecular Formula

——
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. E.J. Roeland, et al. 1696TiP Phase Ib study to assess the effect of PF-06946860 on appetite following subcutaneous administration in patients with anorexia and advanced cancer. VOLUME 32, SUPPLEMENT 5, S1185, SEPTEMBER 01, 2021. Annals of oncology.

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