H-Ile-Lys-Val-Ala-Val-OH

Research use only, not for human use.

H-Ile-Lys-Val-Ala-Val-OH (IKVAV) is a short peptide with a sequence length of 5, present in the extracellular matrix (ECM), on the α-laminin chain.

H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways.

Cell Proliferation Assay Cell Line:BMMSCConcentration:0, 0.004, 0.02, 0.1, 0.5 and 2.5 mMIncubation Time:0, 12, 24, 36, 48 hResult:Stimulated proliferating cell nuclear antigen (PCNA) synthesis and induced proliferation of bone marrow mesenchymal stem cell (BMMSC) in a dose- and time-dependent manner.Cell Cycle Analysis Cell Line:BMMSC Concentration:5 mM Incubation Time:24 hResult:Induced the BMMSC cell cycle for cells to enter S phase from G0/G1 and arrested them from entering G2/M phase; the increased proportion of S phase in cell cycle was considered to be a sign of BMMSC proliferation.Western Blot Analysis Cell Line:BMMSC Concentration:0, 0.004, 0.02, 0.1, 0.5 and 2.5 mM Incubation Time:0, 12, 24, 36, 48 h Result:Increased significantly the levels of p-ERK1/2 and p-Akt in a dose- and time-dependent manner.

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Others

Other Targets

Others

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131167-89-0

528.69

C25H48N6O6

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (189.15 mM; Ultrasonic)

[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(O)=O)=O)C)=O)C(C)C)=O)(NC([C@H]([C@H](CC)C)N)=O)CCCCN

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(-20℃)

With Ice Pack

≥ 2 years