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Retatrutide
CAS No. 2381089-83-2
Retatrutide( —— )
Catalog No. M36652 CAS No. 2381089-83-2
Retatrutide (LY3437943) is a triple agonist of the glucagon receptor, glucose-dependent insulinotropic polypeptide receptor, and glucagon-like peptide-1 receptor (GLP-1R), and inhibits GCGR, GIPR, and GLP-1R.Retatrutide can be used to study obesity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 375 | Get Quote |
|
| 5MG | 591 | Get Quote |
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| 10MG | 947 | Get Quote |
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| 25MG | 1352 | Get Quote |
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| 50MG | 1831 | Get Quote |
|
| 100MG | 2421 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameRetatrutide
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NoteResearch use only, not for human use.
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Brief DescriptionRetatrutide (LY3437943) is a triple agonist of the glucagon receptor, glucose-dependent insulinotropic polypeptide receptor, and glucagon-like peptide-1 receptor (GLP-1R), and inhibits GCGR, GIPR, and GLP-1R.Retatrutide can be used to study obesity.
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DescriptionRetatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity.
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In Vitro——
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In VivoAnimal Model:Diet-induced obese (DIO) male C57/Bl6 mice (24-25 weeks, 40-51 g) Dosage:10 mL/kg Administration:Subcutaneous (SC) injection, cycle every 3 days, for 21 days Result:Decreased body weight and improved glycemic control.
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Synonyms——
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PathwayGPCR/G Protein
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TargetGlucagon Receptor
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RecptorGlucagon Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2381089-83-2
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Formula Weight4731.33
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Molecular FormulaC221H342N46O68
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (10.57 mM; Ultrasonic ) H2O : 33.33 mg/mL (7.04 mM; ultrasonic and adjust pH to 7 with NaOH)
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tamer Coskun, et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept. Cell Metab. 2022 Sep 6;34(9):1234-1247.e9.?
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