MAHMA NONOate

Research use only, not for human use.

MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.

MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP.

MAHMA NONOate (0.1 nM-100 μM) dose-dependently inhibits platelet aggregation induced by either collagen or ADP.MAHMA NONOate shows inhibitory effects to pulmonary artery and platelet aggregation with log IC50 values of 7.18 and 6.16, respectively.

MAHMA NONOate (0.3-10 nmol/kg/min; i.v. once) shows both platelet inhibitory and vasodepressor effects in vivo.Animal Model:Male Wistar rats anaesthetised with pentobarbitone Dosage:0.3-10 nmol/kg/min Administration:Intravenous injection; 0.3-10 nmol/kg/min once Result:Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP.

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Proteasome/Ubiquitin

Endogenous Metabolite

Endogenous Metabolite | NO Synthase

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146724-86-9

204.27

C8H20N4O2

>98% (HPLC)

In Vitro:?H2O : 62.5 mg/mL (305.97 mM; adjust pH to 10 with NaOH)

O=NN(O)N(C)CCCCCCNC

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(-20℃)

With Ice Pack

≥ 2 years