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TNG908

CAS No. 2760481-53-4

TNG908( —— )

Catalog No. M36534 CAS No. 2760481-53-4

TNG908 is an orally active and selective MTAP-co-PRMT5 inhibitor that crosses the blood-brain barrier and kills MTAP-deficient cancers.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 161 In Stock
5MG 148 In Stock
10MG 236 In Stock
25MG 377 In Stock
50MG 529 In Stock
100MG 731 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    TNG908
  • Note
    Research use only, not for human use.
  • Brief Description
    TNG908 is an orally active and selective MTAP-co-PRMT5 inhibitor that crosses the blood-brain barrier and kills MTAP-deficient cancers.
  • Description
    TNG908 is a MTAP-cooperative PRMT5 inhibitor that can pass through the blood-brain barrier. TNG908 is 15 times more selective for MTAP null cell lines than MTAPWT cell lines, and can be used in cancer research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Histone Methyltransferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2760481-53-4
  • Formula Weight
    409.51
  • Molecular Formula
    C21H23N5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (244.20 mM; Ultrasonic )
  • SMILES
    C(C(NC=1C=C(C)C(N)=NC1)=O)(=O)N2[C@H](CC[C@H](C)C2)C=3C=C4C(=CC3)SC=N4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. K. Briggs, et al. TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor for the treatment of MTAP-deleted cancer.MOLECULAR TARGETED AGENTS 2
?VOLUME 174, SUPPLEMENT 1,?S84,?OCTOBER 2022.
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