SRI-42127
CAS No. 2727872-68-4
SRI-42127( —— )
Catalog No. M36510 CAS No. 2727872-68-4
SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | In Stock |
|
| 10MG | 242 | In Stock |
|
| 25MG | 487 | In Stock |
|
| 50MG | 677 | In Stock |
|
| 100MG | 916 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1832 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSRI-42127
-
NoteResearch use only, not for human use.
-
Brief DescriptionSRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response.
-
DescriptionSRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorHuR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2727872-68-4
-
Formula Weight348.4
-
Molecular FormulaC19H20N6O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (143.51 mM; Ultrasonic (<60°C)
-
SMILESN1=CC=2C=CC(=CC2N1)C3=CN=C4C=CC(=NN43)N(C)C5CCOCC5
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Chellappan R, et al. SRI-42127, a novel small molecule inhibitor of the RNA regulator HuR, potently attenuates glial activation in a model of lipopolysaccharide-induced neuroinflammation. Glia. 2022 Jan;70(1):155-172. ?
molnova catalog
related products
-
Hupehenine
Hupehenine is a steriodal alkaloid extracted from the bulbs of Fritillaria Hupehensis, with the potential for inhibiting acetylcholine, antagonism for muscarinic receptors and cholinesterase inhibition.
-
Isostearic acid
Isostearic acid (Isooctadecanoic acid) is an active ingredient in imiquimod formulations that promotes the entry of imiquimod or peripherally secreted cytokines into the brain, and can be used to induce psoriasis-like disease models.
-
Kuwanon O
Kuwanon O is a flavonoid derivative with a fused dihydrochalcone partial moiety, that can be isolated from the root bark of Morus lhou (set.) Koidz.
Cart
sales@molnova.com