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BSJ-04-122
CAS No. 2513289-74-0
BSJ-04-122( —— )
Catalog No. M36505 CAS No. 2513289-74-0
BSJ-04-122 is a covalent dual inhibitor of MKK4 and MKK7, demonstrating IC50 values of 4 nM and 181 nM, respectively. [BSJ-04-122] can be used for cancer research.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 71 | In Stock |
|
| 10MG | 114 | In Stock |
|
| 25MG | 229 | In Stock |
|
| 50MG | 363 | In Stock |
|
| 100MG | 579 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBSJ-04-122
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NoteResearch use only, not for human use.
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Brief DescriptionBSJ-04-122 is a covalent dual inhibitor of MKK4 and MKK7, demonstrating IC50 values of 4 nM and 181 nM, respectively. [BSJ-04-122] can be used for cancer research.
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DescriptionBSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used for the research of cancer.
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In VitroWestern Blot Analysis Cell Line:MDA-MB-231 cells Concentration:1, 5, 10 μM Incubation Time:6 h Result:Significantly decreased levels of T183/Y185 pJNK at 5 μM.Cell Proliferation Assay Cell Line:MDA-MB-231 cells Concentration:1-100 μM; 0, 1.25, 2.5, 5, 10, 20 μM Incubation Time:72 h Result:Exhibited antiproliferative effects when combination with JNK-IN-8 in MDA-MB-231 cells.
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetJNK
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RecptorJNK
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Research Area——
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Indication——
Chemical Information
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CAS Number2513289-74-0
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Formula Weight313.74
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Molecular FormulaC15H12ClN5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (318.74 mM; Ultrasonic )
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SMILESN(C1=C2C(NC=C2Cl)=NC=N1)C3=C(NC(C=C)=O)C=CC=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jie Jiang, et al. Discovery of Covalent MKK4/7 Dual Inhibitor. Cell Chem Biol?
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