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Leritrelvir
CAS No. 2923310-64-7
Leritrelvir( —— )
Catalog No. M36492 CAS No. 2923310-64-7
Leritrelvir (RAY1216) is a potent orally active inhibitor of the SARS-CoV-2 main protease, exhibiting a slow-tight binding mechanism with an inhibition constant (Ki) of 8.6 nM .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 753 | In Stock |
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| 10MG | 1216 | In Stock |
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| 25MG | 1872 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLeritrelvir
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NoteResearch use only, not for human use.
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Brief DescriptionLeritrelvir (RAY1216) is a potent orally active inhibitor of the SARS-CoV-2 main protease, exhibiting a slow-tight binding mechanism with an inhibition constant (Ki) of 8.6 nM .
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DescriptionLeritrelvir (RAY1216) is an orally active SARS-CoV-2 main protease slow-tight inhibitor with a Ki of 8.6 nM.
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In VitroCell Viability Assay Cell Line:Vero E6 cells inoculated with SARS-CoV-2 WT, Alpha, Beta, Delta, Omicron BA.1 and Omicron 247 BA.5 strains Concentration:0-1000 nM Incubation Time:72 h Result:The half-maximal effective concentration (EC50) values against different SARS-CoV-2 variants were 95 nM (WT), 130 nM (Alpha), 277 nM (Beta), 97 nM (Delta), 86 nM (Omicron BA.1) and 158 nM (Omicron BA.5), respectively.
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In VivoOral bioavailabilityAnimal Model:Female human ACE2 transgenic C57BL/6 mouse, SARS-CoV-2 infection modelDosage:150, 300 and 600 mg/kg/day Administration:Intragastric administration, 5 days Result:Protected mice infected with SARS-CoV-2 by 100%, 43% and 14% at 600, 300 and 150 mg/kg, respectively. Decreased viral titres in lungs significantly compared with the infection-only group. Reduced virus induced pathology. Animal Model:Male CD-1 mouse, male SD rat and male cynomolgus macaque Dosage:1-10 mg/kg Administration:PO or IV (Pharmacokinetic Analysis)Result:Showed promising human pharmacokinetics profile.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorSARS-CoV
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Research Area——
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Indication——
Chemical Information
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CAS Number2923310-64-7
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Formula Weight639.71
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Molecular FormulaC31H44F3N5O6
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CCC(CC1)[C@@H](C(=O)N2C[C@@H]3CCC[C@@H]3[C@H]2C(=O)N[C@@H](C[C@@H]4CCNC4=O)C(=O)C(=O)NC5CCCC5)NC(=O)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen X, et al. Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor. bioRxiv, 2023: 2023.03. 09.531862.
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