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Antitumor agent-87
CAS No. 1422527-88-5
Antitumor agent-87( —— )
Catalog No. M36465 CAS No. 1422527-88-5
Antitumor agent-87 is a potent compound exhibiting high antitumoral activity, with a Ki value of 0.23 μM for CYP1A1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 411 | In Stock |
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| 10MG | 562 | In Stock |
|
| 25MG | 866 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAntitumor agent-87
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NoteResearch use only, not for human use.
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Brief DescriptionAntitumor agent-87 is a potent compound exhibiting high antitumoral activity, with a Ki value of 0.23 μM for CYP1A1.
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DescriptionAntitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a Ki value of 0.23 μM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity.
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In VitroCell Proliferation Assay Cell Line:MCF7, HT-29, M21 cells Concentration:0-12500 nM Incubation Time:48 h Result:Showed antiproliferative activity with IC50s of 600, >12500, >12500 nM for MCF7, HT-29, M21 cells, respectively.Cell Cycle Analysis Cell Line:MCF7 cells Concentration:1250 nM Incubation Time:Result:Induced the accumulation of the cells in the G2/M phase of 57% and induced disruptions of the cytoskeleton of MCF7 cells.
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In VivoAnimal Model:chick embryos (HT-1080CYP1A1, HT-1080empty, HT-1080 cells) Dosage:0.1 μg/egg Administration:Result:Did not show statistically significant antitumor activity on grafted cell lines devoid of CYP1A1 (HT-1080 and HT-1080empty), showed antitumoral inhibition of 29% on the grafted HT-1080CYP1A1.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1422527-88-5
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Formula Weight448.53
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Molecular FormulaC22H28N2O6S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1N(C2=CC=C(C=C2)S(=O)(=O)OC=3C=C(OC)C=C(OC)C3)CCN1CCCCC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chavez Alvarez AC, et al. Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes. J Med Chem. 2023 Feb 23;66(4):2477-2497. ?
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