Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - PARP - PARP1/2/TNKS1/2-IN-1

PARP1/2/TNKS1/2-IN-1

CAS No. 2243453-32-7

PARP1/2/TNKS1/2-IN-1( —— )

Catalog No. M36459 CAS No. 2243453-32-7

PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1, and TNKS2, with potential anti-tumor activity that induces apoptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 95 In Stock
10MG 134 In Stock
25MG 163 In Stock
50MG 189 In Stock
100MG 247 In Stock
200MG 365 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PARP1/2/TNKS1/2-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1, and TNKS2, with potential anti-tumor activity that induces apoptosis.
  • Description
    PARP1/2/TNKS1/2-IN-1 (Compound I-9) is a dual PARP-1, PARP-2, TNKS1 and TNKS2 inhibitor with IC50 values of 0.25 nM, 1.2 nM, 13.5 nM and 4.15 nM against PARP-1, PARP-2, TNKS1 and TNKS2, respectively. PARP1/2/TNKS1/2-IN-1 exhibits favorable synergistic antitumor efficacy and induces apoptosis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP | Apoptosis | Wnt/beta-catenin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2243453-32-7
  • Formula Weight
    634.66
  • Molecular Formula
    C35H31FN6O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COC1=CC=C(NC(C2=CC=C(NC(N3CCN(CC3)C(C4=CC(CC5=NNC(C6=C5C=CC=C6)=O)=CC=C4F)=O)=O)C=C2)=O)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xu Y, et al. Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy. Eur J Med Chem. 2022 Jul 5;237:114417. ?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • PARP-1-IN-3

    PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.

  • 4-amino-1,8-Naphthal...

    4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM.

  • Rucaparib phosphate

    An inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay.

Sign In Join Free