CDK8-IN-12

Research use only, not for human use.

CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent.

CDK8-IN-12 is an orally active, potent CDK8 inhibitor with a Ki of 14 nM. CDK8-IN-12 has off-target kinase inhibition on GSK-3α, GSK-3β, PCK-θ with Kis of 13 nM, 4 nM, 109 nM, respectively. CDK8-IN-12 shows potent anti-proliferative effects selectively on MV4-11 cell. CDK8-IN-12 is an anti-cancer agent.

Western Blot Analysis Cell Line:MV4-11 cells Concentration:0.36, 0.72 μM Incubation Time:2 hours Result:Significantly reduced the phosphorylation of serine 727 on STAT1 at concentrations of their respective 1× GI50 values, but barely affected the level of total STAT1.

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PI3K/Akt/mTOR signaling

GSK-3

GSK-3 | CDK

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2613307-67-6

381.86

C21H20ClN3O2

>98% (HPLC)

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O=C1C2(CCN(CC2)C=3C(=CN=CC3Cl)C4=CC=5C(O4)=CC=CC5)CCN1

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(-20℃)

With Ice Pack

≥ 2 years