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ASC-JM-17

CAS No. 1039760-91-2

ASC-JM-17( —— )

Catalog No. M36370 CAS No. 1039760-91-2

ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones.

Purity : >98% (HPLC)

COA

Datasheet

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HPLC

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Biological Information

Product Name

ASC-JM-17
Note

Research use only, not for human use.
Brief Description

ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones.
Description

ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. ASC-JM17 ameliorates toxicity of the mutant androgen receptor (AR) responsible for SBMA in cell, fly and mouse models. Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap ‘n’ collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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Chemical Information

CAS Number

1039760-91-2
Formula Weight

464.55
Molecular Formula

C28H32O6
Purity

>98% (HPLC)
Solubility

——
SMILES

C(CC1CCC1)(C(/C=C/C2=CC(OC)=C(OC)C=C2)=O)C(/C=C/C3=CC(OC)=C(OC)C=C3)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

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