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BAY-069
CAS No. 2639638-66-5
BAY-069( —— )
Catalog No. M36084 CAS No. 2639638-66-5
BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 162 | In Stock |
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| 2MG | 88 | In Stock |
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| 5MG | 147 | In Stock |
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| 10MG | 238 | In Stock |
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| 25MG | 377 | In Stock |
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| 50MG | 529 | In Stock |
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| 100MG | 731 | In Stock |
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| 200MG | 1004 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBAY-069
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NoteResearch use only, not for human use.
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Brief DescriptionBAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at IC50:153 nM.
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DescriptionBAY-069 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50 values of 31 nM and 153 nM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used tor research anticancer.
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In VitroBAY-069 (compound 36a) (70 nM-50 μM; 72 h) inhibits cell proliferation of U-87 and MDA-MB-231.Cell Proliferation Assay Cell Line:U-87 and MDA-MB-231 Concentration:70 nM-50 μM Incubation Time:72 h Result:Inhibited cell proliferation of U-87 and MDA-MB-231 with IC50s of 358 nM and 874 nM, respectively.
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In VivoBAY-069 exhibits high metabolic stability after incubation with human liver microsomes (CLblood = 0.11 L/h/kg) and moderate metabolic stability after incubation with rat hepatocytes (CLblood = 1.8 L/h/kg); shows high permeability through Caco-2 cell monolayers with no hint of efflux.BAY-069 (0.3 mg/kg for i.v.; 0.6 mg/kg for p.o.; single dosage) exhibits a favorable pharmacokinetic profile after i.v. dosing with low blood clearance (CLblood), moderate volume of distribution at steady state (Vss), and intermediate terminal half-life (t1/2).Animal Model:Male Wistar rats Dosage:0.3 mg/kg for i.v.; 0.6 mg/kg for p.o.Administration:i.v. or p.o.; single dosage Result:Pharmacokinetic Parameters of BAY-069 in male Wistar rats.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorReactive Oxygen Species
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Research Area——
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Indication——
Chemical Information
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CAS Number2639638-66-5
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Formula Weight446.81
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Molecular FormulaC22H14ClF3N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (447.62 mM; Ultrasonic )
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SMILESO=C1N(C=2C3=C(C(Cl)=C(OC4=C(C)C=CC=C4)C2)C=CC=C3)C(=O)NC(C(F)(F)F)=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Cathepsin S substrat...
Ac-KQKLR-AMC (Cathepsin S substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin S is a cysteine proteinase involved in the pathogenesis of autoimmune diseases, atherosclerosis, cancer, obesity and related diseases.This peptide is a cathepsin S substrate fluorescently labeled with AMC (Ex/Em=354 nm/442 nm). It can be used to measure cathepsin S activity.)
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Ximoprofen
Ximoprofen is a novel anti-inflammatory compound for the study of spondylitis.
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4-Pentenoic acid
4-Pentenoic acid also known as allyl acetic acid or 4-pentenate belongs to the class of organic compounds known as straight chain fatty acids. These are fatty acids with a straight aliphatic chain. 4-Pentenoic acid is a very hydrophobic molecule practically insoluble (in water) and relatively neutral.
