SRD5A1-IN-1

Research use only, not for human use.

SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 μM).

SRD5A1-IN-1 (Compound 4) is a competitive and covalent steroid 5α-reductase type 1 (SRD5A1) inhibitor with an IC50 of 1.44 μM. SRD5A1-IN-1 modulates SRD5A1 function, leading to a lower level of dihydrotestosterone (DHT) production and SRD5A1 protein suppression.

Western Blot Analysis Cell Line:HaCaT Concentration:0.5, 1, and 2.5 μM Incubation Time:12 h and 24 hResult:Showed a significant decrease in SRD5A1 protein expression at 1 and 2.5 μM at 24 h, whereas there were no significant changes in the level of SRD5A1 protein at 12 h.RT-PCR Cell Line:HaCaT Concentration:0.5, 1, and 2.5 μM Incubation Time:12 h and 24 h Result:Did not affect the mRNA expression of SRD5A1 at both incubation times.Cell Cytotoxicity Assay Cell Line:HaCaT Concentration:0.2, 0.5, 1, and 2.5 μM Incubation Time:24 h Result:Displayed no significant cytotoxicity (IC50: 29.99?±?8.69 μM).

——

——

Others

Other Targets

Others

——

——

2279077-93-7

391.27

C17H11F6NO3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (255.58 mM; Ultrasonic )

N(C(/C=C/C1=CC(O)=C(O)C=C1)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2

——

(-20℃)

With Ice Pack

≥ 2 years