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TH1760

CAS No. 2567914-01-4

TH1760( —— )

Catalog No. M36034 CAS No. 2567914-01-4

TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

TH1760
Note

Research use only, not for human use.
Brief Description

TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM).
Description

TH1760 is an inhibitor of NUDIX-type 15 (NUDT15) with an IC50 value of 25 nM. TH1760 sensitizes cells to 6-thioguanine by enhancing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 enhances the anti-leukemia effect of thiopurine.
In Vitro

Western Blot Analysis Cell Line:HCT116 cells.Concentration:10 μM.Incubation Time:4 h.Result:Inhibited the expression of NUDT15.Western Blot Analysis Cell Line:AML HL-60 cells.Concentration:10 μM.Incubation Time: 3 h.Result:Significantly inhibited the expression of NUDT15 when the temperature was higher than 54℃.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

NUDIX hydrolase
Research Area

——
Indication

——

Chemical Information

CAS Number

2567914-01-4
Formula Weight

426.45
Molecular Formula

C20H18N4O5S
Purity

>98% (HPLC)
Solubility

——
SMILES

S(=O)(=O)(C=1C=C2C(=CC1)NC(=O)O2)N3CCN(C(=O)C=4C=C5C(=CC4)NC=C5)CC3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Zhang SM, et al. Development of a chemical probe against NUDT15. Nat Chem Biol. 2020 Oct;16(10):1120-1128. ?

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