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AZD0095

CAS No. 2750001-23-9

AZD0095( —— )

Catalog No. M35816 CAS No. 2750001-23-9

AZD0095 is a selective inhibitor of MCT4 with an IC50 of 1.3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 217 Get Quote
10MG 353 Get Quote
25MG 532 Get Quote
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Biological Information

  • Product Name
    AZD0095
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD0095 is a selective inhibitor of MCT4 with an IC50 of 1.3 nM.
  • Description
    AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib (HY-10205).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Murine NCI-H358 xenograft Dosage:100 mg/kg together with Cediranib (3 mg/kg) Administration:Oral administration (p.o.)Result:Reduced tumor growth more efficiently than AZD0095 or AZD2171 alone.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Monocarboxylate Transporter
  • Recptor
    Monocarboxylate transporter
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2750001-23-9
  • Formula Weight
    500.6
  • Molecular Formula
    C27H32N8O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 10 mg/mL (19.98 mM; Ultrasonic )
  • SMILES
    Cc1nc2nc(C)c(O[C@@H]3CCN(C3)c3ccc(cc3)-c3ccc(CN4CCOCC4)nn3)c(C)n2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Goldberg FW, et al. Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. J Med Chem. 2022 Dec 16. ?
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