AZD0095( —— )

Catalog No. M35816 CAS No. 2750001-23-9

AZD0095 is a selective inhibitor of MCT4 with an IC50 of 1.3 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	282	In Stock
5MG	217	In Stock
10MG	353	In Stock
25MG	549	In Stock
50MG	775	In Stock
100MG	1070	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

AZD0095
Note

Research use only, not for human use.
Brief Description

AZD0095 is a selective inhibitor of MCT4 with an IC50 of 1.3 nM.
Description

AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib (HY-10205).
In Vitro

——
In Vivo

Animal Model:Murine NCI-H358 xenograft Dosage:100 mg/kg together with Cediranib (3 mg/kg) Administration:Oral administration (p.o.)Result:Reduced tumor growth more efficiently than AZD0095 or AZD2171 alone.
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

Monocarboxylate Transporter
Recptor

Monocarboxylate transporter
Research Area

——
Indication

——

Chemical Information

CAS Number

2750001-23-9
Formula Weight

500.6
Molecular Formula

C27H32N8O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 10 mg/mL (19.98 mM; Ultrasonic )
SMILES

Cc1nc2nc(C)c(O[C@@H]3CCN(C3)c3ccc(cc3)-c3ccc(CN4CCOCC4)nn3)c(C)n2n1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Goldberg FW, et al. Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. J Med Chem. 2022 Dec 16. ?

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks