Cart
sales@molnova.com
Home - Products - MAPK/ERK Signaling - Raf - Exarafenib

Exarafenib

CAS No. 2639957-39-2

Exarafenib( —— )

Catalog No. M35731 CAS No. 2639957-39-2

Exarafenib (RAF/KIN_2787) is a potent, orally available pan-RAF inhibitor with antitumor activity that acts by inhibiting downstream MAPK pathway signaling. It is used in cancer research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 312 In Stock
10MG 534 In Stock
25MG 803 In Stock
50MG 1014 In Stock
100MG 1386 In Stock
200MG Get Quote In Stock
500MG 2771 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Exarafenib
  • Note
    Research use only, not for human use.
  • Brief Description
    Exarafenib (RAF/KIN_2787) is a potent, orally available pan-RAF inhibitor with antitumor activity that acts by inhibiting downstream MAPK pathway signaling. It is used in cancer research.
  • Description
    Exarafenib (RAF/KIN_2787) is an orally-available, selective pan-RAF inhibitor. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. Exarafenib has anticancer activity.
  • In Vitro
    Cell Viability AssayCell Line:Melanoma cell (A375 BRAFV600E, HMVII BRAFG469V; NRASQ61K, WM3629 BRAFD594G; NRASG12D, SKMEL2 NRASQ61R) Concentration:1-10000 nM Incubation Time:24 h Result:Inhibited RAF-dependent melanoma cell line growth.
  • In Vivo
    Animal Model:BALB/c nude mice xenograft models of BRAF and NRAS-mutant melanoma Dosage:3, 5, 10, 20, 30 mg/kg Administration:Orally; twice daily (BID); 29 days Result:Was effective against BRAFmut & NRASmut human melanoma xenografts in vivo.
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    Raf
  • Recptor
    Raf | p38 MAPK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2639957-39-2
  • Formula Weight
    521.58
  • Molecular Formula
    C26H34F3N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (191.73 mM; Ultrasonic )
  • SMILES
    C[C@H](CO)Nc1cc(cc(n1)N1CCOCC1)-c1cc(NC(=O)N2CC[C@@H](CC(F)(F)F)C2)ccc1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Miller N, et, al. Antitumor activity of KIN-2787, a next-generation pan-RAF inhibitor, in combination with MEK inhibition in preclinical models of human NRAS mutant melanoma.2022 Jun 2;40(16): e15099.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • BRAF inhibitor 13

    A potent and selective B-Raf inhibitor with IC50 of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively.

  • RAS GTPase inhibitor...

    RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.

  • Sorafenib

    A potent, orally available Raf inhibitor with IC50 of 6, 22, and 38 nM for Raf-1, wt Braf, and BRaf V599E, respectively.

Sign In Join Free