Sitafloxacin

Research use only, not for human use.

Sitafloxacin (Sitafloxacin anhydrous) is an orally active fluoroquinolone antibiotic with broad-spectrum antimicrobial activity.Sitafloxacin has been used in the study of respiratory tract infections and urinary tract infections.

Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection.

Sitafloxacin (DU6859a) shows antibacterial activities with MIC of 0.03, 0.12, 0.06 mg/L for wild-type ATCC 49619, gyrA mutant SP39, parCmutant 1026523 streptococcus pneumoniae stran, respectively. Sitafloxacin (DU6859a) shows antibacterial activities for quinolone-susceptible strains of streptococcus pneumoniae with MIC of 0.03, 0.03 mg/L for EG 00093 and EG 00218 strain, respectively.Sitafloxacin (DU6859a) shows inhibition for DNA gyrase and topoisomerase IV (TopoIV) with >IC50s of 4.38, 3.12 mg/L, respectively.

Sitafloxacin (DU-6859a) (12.5-100 mg/kg; i.g.; daily for 4 weeks; BALB/c female mice) has antibacterial activity. M. ulcerans cells could be isolated from the inoculated footpads and there was no evidence of footpad swelling.Animal Model:BALB/c female mice Dosage:12.5, 25, 50 and 100 mg/kg Administration:Oral gavage; daily, for 4 weeks Result:Inhibits the growth of Mycobacterium ulcerans and the M. ulcerans cells.

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Microbiology/Virology

Antibiotic

Antibiotic

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127254-12-0

409.81

C19H18ClF2N3O3

>98% (HPLC)

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N[C@H]1C2(CN(C1)C=3C(Cl)=C4N(C=C(C(O)=O)C(=O)C4=CC3F)[C@H]5[C@@H](F)C5)CC2

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(-20℃)

With Ice Pack

≥ 2 years