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Tribendimidine
CAS No. 115103-15-6
Tribendimidine( —— )
Catalog No. M35670 CAS No. 115103-15-6
Tribendimidine is a broad-spectrum, orally active anthelmintic and an L-type nicotinic acetylcholine receptor (nAChR) agonist. tribendimidine is highly active against A. lumbricoides and N. americanus.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 46 | In Stock |
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| 10MG | 78 | In Stock |
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| 25MG | 153 | In Stock |
|
| 50MG | 229 | In Stock |
|
| 100MG | 337 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTribendimidine
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NoteResearch use only, not for human use.
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Brief DescriptionTribendimidine is a broad-spectrum, orally active anthelmintic and an L-type nicotinic acetylcholine receptor (nAChR) agonist. tribendimidine is highly active against A. lumbricoides and N. americanus.
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DescriptionTribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist.
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In VitroTribendimidine (100 μg/mL; 24 h) shows intoxication of C. elegans.Tribendimidine (0-100 μg/mL; 6 days) shows toxicity with an LC50 value (concentration at which half the animals are dead) of 54.4 μg/mL.Tribendimidine (0-200 μg/mL; 64 h)-induced sterility is resisted by trb mutant hermaphrodites, and Levamisole-resistant mutants are resistant to Tribendimidine.
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In VivoTribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters.Animal Model:C. sinensis infected Female Wistar rats Dosage:75 mg/kg and 150 mg/kg Administration:Oral administration, once Result:A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetAChR
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RecptorAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number115103-15-6
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Formula Weight452.59
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Molecular FormulaC28H32N6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (110.48 mM; Ultrasonic; (HCL ，pH≈3); )
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SMILESCN(C)C(\C)=N\c1ccc(cc1)\N=C\c1ccc(\C=N\c2ccc(cc2)\N=C(/C)N(C)C)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xiao SH, et al. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005 Apr;94(1):1-14.?
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