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ALOX15-IN-2
CAS No. 2764818-23-5
ALOX15-IN-2( —— )
Catalog No. M35657 CAS No. 2764818-23-5
ALOX15-IN-2 is a potent inhibitor of ALOX15 linoleate oxygenase activity, inhibiting the oxidation of linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, with IC50s of 1.55 and 2.79 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 102 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 163 | In Stock |
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| 25MG | 330 | In Stock |
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| 50MG | 555 | In Stock |
|
| 100MG | 792 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1609 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameALOX15-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionALOX15-IN-2 is a potent inhibitor of ALOX15 linoleate oxygenase activity, inhibiting the oxidation of linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, with IC50s of 1.55 and 2.79 μM, respectively.
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DescriptionALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetLipoxygenase
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RecptorLipoxygenase
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Research Area——
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Indication——
Chemical Information
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CAS Number2764818-23-5
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Formula Weight443.56
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Molecular FormulaC23H29N3O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (225.45 mM; Ultrasonic )
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SMILESN(S(NC(OCCCCCCCC)=O)(=O)=O)C=1C=C(C2=CC=3C(N2)=CC=CC3)C=CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Golovanov A, et al. N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action. J Med Chem. 2022;65(3):1979-1995. ?
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