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Home - Products - Immunology/Inflammation - Lipoxygenase - ALOX15-IN-2

ALOX15-IN-2

CAS No. 2764818-23-5

ALOX15-IN-2( —— )

Catalog No. M35657 CAS No. 2764818-23-5

ALOX15-IN-2 is a potent inhibitor of ALOX15 linoleate oxygenase activity, inhibiting the oxidation of linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, with IC50s of 1.55 and 2.79 μM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ALOX15-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    ALOX15-IN-2 is a potent inhibitor of ALOX15 linoleate oxygenase activity, inhibiting the oxidation of linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, with IC50s of 1.55 and 2.79 μM, respectively.
  • Description
    ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    Lipoxygenase
  • Recptor
    Lipoxygenase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2764818-23-5
  • Formula Weight
    443.56
  • Molecular Formula
    C23H29N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (225.45 mM; Ultrasonic )
  • SMILES
    N(S(NC(OCCCCCCCC)=O)(=O)=O)C=1C=C(C2=CC=3C(N2)=CC=CC3)C=CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Golovanov A, et al. N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action. J Med Chem. 2022;65(3):1979-1995. ?
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