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WIN 54954

CAS No. 107355-45-3

WIN 54954( —— )

Catalog No. M35578 CAS No. 107355-45-3

WIN 54954 is an orally available antiviral agent that inhibits Coxsackievirus and inhibits viral translation or transcription.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 116 In Stock
5MG 103 In Stock
10MG 168 In Stock
25MG 306 In Stock
50MG 481 In Stock
100MG 770 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    WIN 54954
  • Note
    Research use only, not for human use.
  • Brief Description
    WIN 54954 is an orally available antiviral agent that inhibits Coxsackievirus and inhibits viral translation or transcription.
  • Description
    WIN 54954 is an orally active and broad-spectrum antipicornavirus agent. WIN 54954 is effectiveness against human rhinovirus, echovirus 9 and enterovirus infections.
  • In Vitro
    WIN 54954 reduces plaque formation of 50 of 52 rhinovirus serotypes (MICs ranges from 0.007 to 2.2 μg/mL).WIN 54954 inhibits 15 commonly isolated enteroviruses, with an EC80 of 0.06 μg/mL.
  • In Vivo
    WIN 54954 (2-100 mg/kg; p.o.) protects 50% of the mice from developing paralysis following infection with coxsackievirus A-9 and echovirus-9 at the dose of 2 and 100 mg/kg, respectively.
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    Antiviral
  • Recptor
    Antiviral
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    107355-45-3
  • Formula Weight
    383.27
  • Molecular Formula
    C18H20Cl2N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (260.91 mM; Ultrasonic )
  • SMILES
    Cc1cc(CCCCCOc2c(Cl)cc(cc2Cl)C2=NCCO2)on1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Woods MG, et, al. In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug. Antimicrob Agents Chemother. 1989 Dec;33(12):2069-74.?
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