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Diaziquone
CAS No. 57998-68-2
Diaziquone( —— )
Catalog No. M35553 CAS No. 57998-68-2
Diaziquone (NSC-182986) is a water-soluble synthetic azacyclic benzoquinone that enhances penetration of the blood-brain barrier, has antitumor activity, and is used in the treatment of extreme renal failure.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 353 | In Stock |
|
| 10MG | 566 | In Stock |
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| 25MG | 927 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDiaziquone
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NoteResearch use only, not for human use.
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Brief DescriptionDiaziquone (NSC-182986) is a water-soluble synthetic azacyclic benzoquinone that enhances penetration of the blood-brain barrier, has antitumor activity, and is used in the treatment of extreme renal failure.
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DescriptionDiaziquone (Diaziquone) is a water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity.
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In Vitro——
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In VivoDiaziquone (6.75mg /sq m daily for 5 consecutive days or single-dose 26 mg/sq m) has a broad range of activity of diaziquone against primary nervous system tumors and has enhancement effect combined with either 1,3-bis(2-chloroethyl)-1-nitrosourea or procarbazine in athymic mice.Animal Model:Homozygous nu/nu BALB/c athymic mice Dosage:6.75mg /sq m or 26 mg/sq m Administration:6.75mg /sq m daily for 5 consecutive days or single-dose 26 mg/sq m Result:Showed rapid clearance in the plasma of athymic mice with a half-life of approximately 11.5 min.Produced significant growth delays.Produced significant increases in the median growth delay, significant increases in the number of tumor regressions.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number57998-68-2
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Formula Weight364.35
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Molecular FormulaC16H20N4O6
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C(OCC)=O)C1=C(C(=O)C(NC(OCC)=O)=C(C1=O)N2CC2)N3CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. S C Schold Jr, et al. Treatment of human glioma and medulloblastoma tumor lines in athymic mice with diaziquone and diaziquone-based drug combinations. Cancer Res. 1984 Jun;44(6):2352-7.?
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