Cart
sales@molnova.com
Home - Products - Others - Other Targets - ARN25068

ARN25068

CAS No. 2649882-80-2

ARN25068( —— )

Catalog No. M35549 CAS No. 2649882-80-2

ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 107 In Stock
10MG 180 In Stock
25MG 359 In Stock
50MG 576 In Stock
100MG 923 In Stock
200MG 1237 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    ARN25068
  • Note
    Research use only, not for human use.
  • Brief Description
    ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation .
  • Description
    ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation.
  • In Vitro
    ARN25068 reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line. ARN25068 exhibits IC50 values of 4.17 and 2.17 μM for GSK-3β and FYN in enzymatic radiometric assay, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Microtubule Associated | Src | DYRK | GSK-3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2649882-80-2
  • Formula Weight
    362.45
  • Molecular Formula
    C19H18N6S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (551.80 mM; Ultrasonic )
  • SMILES
    N(C1=C2C(=NC(NCC3=CC=CC=C3)=N1)C=CS2)C=4C=C(NN4)C5CC5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Calcitonin Gene Rela...

    Calcitonin Gene Related Peptide (8-37), human

  • Thalidomide-NH-C2-PE...

    Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate.

  • BMS-593214

    BMS-593214 is an active site-directed factor (F) VIIa inhibitor that exhibits antithrombotic and antihaemostatic properties.

Sign In Join Free