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Chromenone 1

CAS No. 1639929-29-5

Chromenone 1( —— )

Catalog No. M35539 CAS No. 1639929-29-5

Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 109 In Stock
5MG 107 In Stock
10MG 157 In Stock
25MG 236 In Stock
50MG 324 In Stock
100MG 442 In Stock
200MG 594 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Chromenone 1
  • Note
    Research use only, not for human use.
  • Brief Description
    Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).
  • Description
    Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.
  • In Vitro
    Chromenone 1 rescues DMH-1-induced cardiogenesis (IC50=0.2 μM) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TGF-beta/Smad
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1639929-29-5
  • Formula Weight
    357.29
  • Molecular Formula
    C18H10F3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (279.88 mM; Ultrasonic )
  • SMILES
    O=C1C(=C(OC=2C1=CC=CC2)N3C=NC=N3)C4=CC=C(C(F)(F)F)C=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wesseler F, et al. Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. J Med Chem. 2022;65(5):3978-3990. ?
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