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Beclobrate

CAS No. 55937-99-0

Beclobrate( —— )

Catalog No. M35519 CAS No. 55937-99-0

Beclobrate (Sgd 24774) is a novel orally available fibric acid derivative that has shown significant lipid and cholesterol-lowering activity in rodents and may be used in the study of primary hyperlipoproteinemia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Beclobrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Beclobrate (Sgd 24774) is a novel orally available fibric acid derivative that has shown significant lipid and cholesterol-lowering activity in rodents and may be used in the study of primary hyperlipoproteinemia.
  • Description
    Beclobrate (Sgd 24774), a Fibric acid derivative, displays remarkable lipid lowering activity in rodents.
  • In Vitro
    ——
  • In Vivo
    On the normal diet rats, Beclobrate lowers total plasma cholesterol by 22-33.4% (10-50 mg/kg); the cholesterol reduction occurred mainly in high density lipoproteins (HDL). In addition, Beclobrate administration dramatically increases the activity of the high-affinity receptors for beta-VLDL in isolated liver membranes.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    55937-99-0
  • Formula Weight
    346.85
  • Molecular Formula
    C20H23ClO3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(OCC)C(OC1=CC=C(C=C1)CC2=CC=C(Cl)C=C2)(C)CC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. C Manzoni, et al. Differential effects of beclobrate on lipid/lipoprotein distribution in normal and hypercholesterolemic rats. Eur J Pharmacol. 1990 Nov 6;190(1-2):39-49.?
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