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Chitin synthase inhibitor 4
CAS No. 2755847-31-3
Chitin synthase inhibitor 4( —— )
Catalog No. M35516 CAS No. 2755847-31-3
Chitin synthase inhibitor 4 is a chitin synthase (CHS) inhibitor with antimicrobial activity.Chitin synthase inhibitor 4 is a CHS-based compound and a candidate fungicide.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 59 | In Stock |
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| 2MG | 31 | In Stock |
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| 5MG | 53 | In Stock |
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| 10MG | 95 | In Stock |
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| 25MG | 195 | In Stock |
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| 50MG | 277 | In Stock |
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| 100MG | 384 | In Stock |
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| 200MG | 510 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameChitin synthase inhibitor 4
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NoteResearch use only, not for human use.
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Brief DescriptionChitin synthase inhibitor 4 is a chitin synthase (CHS) inhibitor with antimicrobial activity.Chitin synthase inhibitor 4 is a CHS-based compound and a candidate fungicide.
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DescriptionChitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture.
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In VitroChitin synthase inhibitor 4 shows good antifungal activities against V. mali and S. sclerotiorum with EC50 values of 0.71 and 2.47 μg/mL, respectively.Chitin synthase inhibitor 4 (50 μg/mL) displays potency inhibition against V. mali and S. sclerotiorum with inhibition rates of 90.3% and 88.7%, respectivelyChitin synthase inhibitor 4 (1 μg/mL) blocks the hyphae growth, results abnormal growth, with inducing cell content decreasing, cell wall degradation, and plasmolysis.Chitin synthase inhibitor 4 (50 μM; 3 h) exhibits inhibition against chitin synthase and polyoxin D with inhibition rates of 68.08% and 63.84%, respectively.
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In VivoChitin synthase inhibitor 4 (50 μg/mL) has considerable curative and protective effects against S. sclerotiorum vivo, and no obvious phytotoxicity .Chitin synthase inhibitor 4 has low acute toxicity, with no carcinogenic and mutagenic toxicity risk.Animal Model:Rat with Salmonella typhimurium Dosage:As Acute Oral Toxicity for Chemicals-Acute Toxic Class Method Administration:Oral gavage Result:Showed acute toxicity of 3.58 as toxicity grading standard, and negative carcinogenic toxicity, negative mutagenic toxicity.
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Synonyms——
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PathwayMicrobiology/Virology
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TargetAntibiotic
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RecptorAntibiotic
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Research Area——
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Indication——
Chemical Information
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CAS Number2755847-31-3
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Formula Weight346.36
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Molecular FormulaC20H15FN4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (288.72 mM; Ultrasonic )
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SMILESFc1c(Oc2ccccc2C#N)ncnc1N1CCCc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang X, et al. Synthesis, Antifungal Activity, and 3D-QASR of Novel 1,2,3,4-Tetrahydroquinoline Derivatives Containing a Pyrimidine Ether Scaffold as Chitin Synthase Inhibitors. J Agric Food Chem. 2022 Jul 21. ?
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