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RP-6306
CAS No. 2719793-90-3
RP-6306( —— )
Catalog No. M35485 CAS No. 2719793-90-3
Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM. Lunresertib (RP-6306) inhibits the growth of CCNE1-amplified tumor cells in several preclinical xenograft models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 558 | In Stock |
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| 5MG | 313 | In Stock |
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| 10MG | 464 | In Stock |
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| 25MG | 747 | In Stock |
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| 50MG | 1014 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRP-6306
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NoteResearch use only, not for human use.
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Brief DescriptionLunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM. Lunresertib (RP-6306) inhibits the growth of CCNE1-amplified tumor cells in several preclinical xenograft models.
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DescriptionRP-6306((S)-RP-6306) is a potent, selective and orally active PKMYT1 inhibitor with an IC50 of 14 nM. RP-6306 shows a high degree of selectivity over other kinases in cellular binding assays. RP-6306 shows anticancer effects.
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In Vitro——
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In VivoAnimal Model:OVCAR3-bearing miceDosage:15, 50, and 300 ppm (equivalent to approximately 3, 10, and 60 mg/kg/day) Administration:Oral; daily; for 21 days Result:Resulted in a statistically significant and dose-dependent reduction in OVCAR3 tumor growth.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetWee1
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RecptorWee1
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Research Area——
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Indication——
Chemical Information
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CAS Number2719793-90-3
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Formula Weight324.38
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Molecular FormulaC18H20N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (154.14 mM; Ultrasonic )
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SMILESNC=1N(C=2C(C1C(N)=O)=CC(C)=C(C)N2)C3=C(C)C(O)=CC=C3C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Janek Szychowski, et al. Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem. 2022 Aug 11;65(15):10251-10284. ?
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