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Lanicemine dihydrochloride
CAS No. 153322-06-6
Lanicemine dihydrochloride( —— )
Catalog No. M35423 CAS No. 153322-06-6
Lanicemine dihydrochloride (AZD-6765 dihydrochloride) is a low-capture NMDA channel blocker with antidepressant activity and can be used to study neurological diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 81 | In Stock |
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| 25MG | 170 | In Stock |
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| 50MG | 276 | In Stock |
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| 100MG | 423 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 918 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLanicemine dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionLanicemine dihydrochloride (AZD-6765 dihydrochloride) is a low-capture NMDA channel blocker with antidepressant activity and can be used to study neurological diseases.
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DescriptionLanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.
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In Vitro——
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In VivoAnimal Model:Male Sprague-Dawley ratsDosage:3, 10 or 30?mg/kg Administration:Intraperitoneal Result:Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetNMDAR
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RecptorNMDAR
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Research Area——
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Indication——
Chemical Information
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CAS Number153322-06-6
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Formula Weight271.19
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Molecular FormulaC13H16Cl2N2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 240 mg/mL (884.99 mM; Ultrasonic )H2O : ≥ 100 mg/mL (368.75 mM)
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SMILESN[C@H](C1=CC=CC=C1)CC2=CC=CC=N2.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.?
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