Cart
sales@molnova.com
NLRP3/AIM2-IN-3
CAS No. 1787787-60-3
NLRP3/AIM2-IN-3( —— )
Catalog No. M35421 CAS No. 1787787-60-3
NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 71 | In Stock |
|
| 5MG | 65 | In Stock |
|
| 10MG | 104 | In Stock |
|
| 25MG | 217 | In Stock |
|
| 50MG | 346 | In Stock |
|
| 100MG | 555 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1172 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNLRP3/AIM2-IN-3
-
NoteResearch use only, not for human use.
-
Brief DescriptionNLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M.
-
DescriptionNLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayNF-κB
-
TargetNOD
-
RecptorNOD | AIM2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1787787-60-3
-
Formula Weight266.29
-
Molecular FormulaC16H14N2O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (938.83 mM; Ultrasonic )Methanol : 50 mg/mL (187.77 mM; Ultrasonic)
-
SMILESOc1cccc(NC(=O)Cc2ccc3cc[nH]c3c2)c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194.?
molnova catalog
related products
-
Nodinitib-1
A potent and selective NOD1 inhibitor with IC50 of 0.56 uM.
-
INF39
INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor.
-
antcin A
antcin A is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea with strong anti-inflammatory and anti-tumor effects.
