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UNC 1025

CAS No. 1350549-36-8

UNC 1025( —— )

Catalog No. M35372 CAS No. 1350549-36-8

UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	209	In Stock
5MG	164	In Stock
10MG	259	In Stock
25MG	428	In Stock
50MG	591	In Stock
100MG	798	In Stock
200MG	Get Quote	In Stock
500MG	1590	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

UNC 1025
Note

Research use only, not for human use.
Brief Description

UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK.
Description

UNC1062 is a MERTK-selective tyrosine kinase inhibitor, reduces activation of MERTK-mediated downstream signaling, induces apoptosis in culture, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. UNC1062 potently inhibits MERTK kinase activity (MERTK IC50=1.1 nM, Morrison Ki=0.33 nM) and exhibits specificity within the TAM family (TYRO3 IC50=60 nM, AXL IC50=85 nM).
In Vitro

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In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

1350549-36-8
Formula Weight

514.64
Molecular Formula

C25H34N6O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 10 mg/mL (19.43 mM; Ultrasonic (<60°C)
SMILES

CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Schlegel J, et al. MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest. 2013;123(5):2257-2267. ?

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