UNC 1025

Research use only, not for human use.

UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK.

UNC1062 is a MERTK-selective tyrosine kinase inhibitor, reduces activation of MERTK-mediated downstream signaling, induces apoptosis in culture, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. UNC1062 potently inhibits MERTK kinase activity (MERTK IC50=1.1 nM, Morrison Ki=0.33 nM) and exhibits specificity within the TAM family (TYRO3 IC50=60 nM, AXL IC50=85 nM).

——

——

——

Others

Other Targets

Others

——

——

1350549-36-8

514.64

C25H34N6O4S

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (19.43 mM; Ultrasonic (<60°C)

CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1

——

(-20℃)

With Ice Pack

≥ 2 years