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CB-5339
CAS No. 1863952-15-1
CB-5339( —— )
Catalog No. M35369 CAS No. 1863952-15-1
p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 48 | In Stock |
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| 10MG | 71 | In Stock |
|
| 25MG | 122 | In Stock |
|
| 50MG | 179 | In Stock |
|
| 100MG | 267 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCB-5339
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NoteResearch use only, not for human use.
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Brief Descriptionp97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM .
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DescriptionCB-5339 is an oral activity potent p97 inhibitor with an IC50 <30 nM. CB-5339 can be used for leukemia research. CB-5339 extracted from WO2015109285A1 compound FF07.
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In VitroWestern Blot AnalysisCell Line:MV4-11 AML cell line Concentration:0,0.2,0.4,0.8,1.6 μM Incubation Time:24-48 hours Result:Induced dose-dependent polyubiquitin protein accumulation at concentrations ≥ 0.4 μM. Induced the ER stress marker GRP78 accumulated at concentrations ≥ 0.4 μM. Induced spliced XBP-1 and ATF-4 accumulated after treatment with CB-5339 at concentrations ≥ 1.6 μM and 0.8 μM respectively arguing for a concentration-dependent increase in proteotoxic stress.
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In VivoAnimal Model:MLL-AF9-driven patient-derived xenograft (PDX) AML model in C57BL/6 male mice Dosage:90 mg/kg Administration:oral gavage (p.o.)Result:Decreased bone marrow leukemic infiltration and circulating leukemic cells.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorp97
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Research Area——
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Indication——
Chemical Information
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CAS Number1863952-15-1
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Formula Weight412.49
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Molecular FormulaC24H24N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (242.43 mM; Ultrasonic (<80°C)
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SMILESCC=1N(C=2C(=C(C(N)=O)C=CC2)C1)C3=NC(NCC4=CC=CC=C4)=C5C(N3)=NCCC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. David Wustrow, et al. FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX. WO2015109285A1.
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