Cart
sales@molnova.com
PBRM1-BD2-IN-2
CAS No. 2819989-57-4
PBRM1-BD2-IN-2( —— )
Catalog No. M35349 CAS No. 2819989-57-4
PBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targeting the PBRM1-BD2 domain, with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 245 | In Stock |
|
| 5MG | 255 | In Stock |
|
| 10MG | 375 | In Stock |
|
| 25MG | 562 | In Stock |
|
| 50MG | 770 | In Stock |
|
| 100MG | 1051 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2111 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePBRM1-BD2-IN-2
-
NoteResearch use only, not for human use.
-
Brief DescriptionPBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targeting the PBRM1-BD2 domain, with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively.
-
DescriptionPBRM1-BD2-IN-2 is a selective and cell-activepolybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer.
-
In VitroPBRM1-BD2-IN-2 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line.PBRM1-BD2-IN-2 has binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B amd SMARCA4 with Kd values of 9.3 μM, 10.1 μM, 18.4 μM and 69 μM, respectively.PBRM1-BD2-IN-2 has inhibitory activity for PBRM1-BD2 with IC50 value of 1.0 μM.Cell Viability Assay Cell Line:Human prostate cell lines LNCaP, PC3, and RWPE-1Concentration:0, 0.1, 1, and 10 μM Incubation Time:5 days Result:Inhibited LNCaP growth at higher concentrations.
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetEpigenetic Reader Domain
-
RecptorEpigenetic Reader Domain
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2819989-57-4
-
Formula Weight311.14
-
Molecular FormulaC14H9Cl2FN2O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1C=2C(NC(N1)C3=C(Cl)C=CC=C3F)=CC=CC2Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Shifali Shishodia, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13.?
molnova catalog
related products
-
ZM223
ZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).
-
ZEN-3219
ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).
-
ZEN-3694
ZEN-3694 (ZEN 3694) is a bromo-structural domain extra-terminal inhibitor (BETi) with activity in androgen signaling inhibitor (ASI) resistance models and can be used in combination with enzalutamide to study metastatic desmoplasia-resistant prostate cancer.
