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SOD1-Derlin-1 inhibitor-1

CAS No. 840461-03-2

SOD1-Derlin-1 inhibitor-1( —— )

Catalog No. M35328 CAS No. 840461-03-2

SOD1-Derlin-1 inhibitor-1 (SOD1-Derlin-1 Inhibitor 56-20) (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1 G93A -Derlin-1 complex with an IC 50 value of 7.11 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 29 In Stock
10MG 46 In Stock
25MG 93 In Stock
50MG 138 In Stock
100MG 207 In Stock
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Biological Information

  • Product Name
    SOD1-Derlin-1 inhibitor-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SOD1-Derlin-1 inhibitor-1 (SOD1-Derlin-1 Inhibitor 56-20) (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1 G93A -Derlin-1 complex with an IC 50 value of 7.11 μM.
  • Description
    SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis.
  • In Vitro
    SOD1-Derlin-1 inhibitor-1 (50 μM; 16 h) inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 (250 nM; 6 h) interacts with SOD1G93A with a Kd value of 81.1 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    840461-03-2
  • Formula Weight
    504.2
  • Molecular Formula
    C19H12Br2N4OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 2.7 mg/mL (5.36 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C)
  • SMILES
    NC=1C=2C(SC1C(NC3=C(Br)C=C(Br)C=C3)=O)=NC(=CC2)C=4C=CC=NC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668.?
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