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PA-8
CAS No. 878437-15-1
PA-8( —— )
Catalog No. M35242 CAS No. 878437-15-1
PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 37 | In Stock |
|
| 10MG | 68 | In Stock |
|
| 25MG | 143 | In Stock |
|
| 50MG | 250 | In Stock |
|
| 100MG | 430 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePA-8
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NoteResearch use only, not for human use.
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Brief DescriptionPA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors.
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DescriptionPA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC50 of 2 nM.
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In Vitro——
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In VivoAnimal Model:Male ddY mice (6 weeks old) injected with PACAP (100 pmol) Dosage:100 pmol/5 μL Administration:Intrathecal injection; once Result:Inhibited PACAP-induced aversive responses and mechanical allodynia in vivo.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPACAP
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Research Area——
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Indication——
Chemical Information
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CAS Number878437-15-1
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Formula Weight342.35
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Molecular FormulaC17H18N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (73.02 mM; Ultrasonic (<60°C)
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SMILESCOc1cc(ccc1OCC=C)C1CC(=O)Nc2nc(N)[nH]c(=O)c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ichiro Takasaki, et al. In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor. J Pharmacol Exp Ther. 2018 Apr;365(1):1-8.?
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