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Cpd27
CAS No. 501693-48-7
Cpd27( —— )
Catalog No. M35217 CAS No. 501693-48-7
Cpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and protects RGCs from TNF-stimulated cell death and can be used to study glaucoma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
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| 5MG | 132 | In Stock |
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| 10MG | 217 | In Stock |
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| 25MG | 436 | In Stock |
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| 50MG | 630 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCpd27
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NoteResearch use only, not for human use.
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Brief DescriptionCpd27 (TIE-2/VEGFR-2 kinase-IN-2) is a TIE-2 and VEGFR-2 inhibitor that inhibits RIPK1 and protects RGCs from TNF-stimulated cell death and can be used to study glaucoma.
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DescriptionTIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetRIP kinase
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RecptorRIP kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number501693-48-7
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Formula Weight431.34
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Molecular FormulaC20H13F4N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (115.92 mM; Ultrasonic )
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SMILESO=C(NC=1C=CC(=CC1)C2=COC3=NC=NC(N)=C32)NC4=CC(=CC=C4F)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yasushi Miyazaki, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8.?
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